It’s something pediatricians are taught to discuss with their young patients: Alcoholism runs in families, they counsel, so if yours has a strong history of this condition, you should be especially careful about drinking. But researchers’ efforts to pin down specific genes that contribute to this heritability have largely come up short. “Nobody has found a smoking gun that says, This is a gene that causes alcoholism,” says Gregg Homanics, a professor of anesthesiology at the University of Pittsburgh (with a PhD in animal science). He and Andrey Finegersh, an MD/PhD student in his lab, decided to try a slightly different tack. “We thought that maybe in alcoholics, drinking a lot would cause some changes in what controls the genes—and that is what gets passed down to the next generation,” says Homanics. The findings from the resulting study were published in PLOS ONE in June.
[Read more at Pitt Med Magazine (scroll down to third story) // Fall 2014]